The Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346: 549-556.
RHH Journal Club. March 14th, 2012. Dr Rishav Goyal
Full-text article (if available)
Does induced hypothermia following cardiac arrest result in an improved neurological outcome?
Cardiac arrest with widespread cerebral ischemia frequently leads to severe neurologic impairment. We studied whether mild systemic hypothermia increases the rate of neurologic recovery after resuscitation from cardiac arrest due to ventricular fibrillation.
Multicentre trial with blinded assessment of the outcome
Patients who had been resuscitated after cardiac arrest were randomly assigned to undergo therapeutic hypothermia (target temperature, 32°C to 34°C) over a period of 24 hours or to receive standard treatment with normothermia.
The primary end point was a favorable neurologic outcome within six months after cardiac arrest
Secondary end points were mortality within six months and the rate of complications within seven days
Seventy-five of the 136 patients in the hypothermia group (55percent) had a favorable neurologic outcome (cerebral performance category, 1 [good recovery] or 2 [moderate disability]), as compared with 54 of 137 (39 percent) in the normothermia group (risk ratio, 1.40; 95 percent confidence interval, 1.08 to 1.81).
Mortality at six months was 41 percent in the hypothermia group (56 of 137 patients died), as compared with 55 percent in the normothermia group (76 of 138 patients; risk ratio, 0.74; 95 percent confidence interval, 0.58 to 0.95).
The complication rate did not differ significantly between the two groups.
In patients who have been successfully resuscitated after cardiac arrest due to ventricular fibrillation, therapeutic mild hypothermia increased the rate of a favorable neurologic outcome and reduced mortality.