The origin of the magic MAC number

Eger EI, Saidman LJ & Brandstater B. Minimum alveolar anesthetic concentration: a standard of anesthetic potency. Anesthesiology 1965; 26:756-763.

RHH Journal Club. July 4th, 2013. Dr Niv Jena

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This seminal body of work performed by Eger and his team in the 1960’s provides the basis for much of how we practice anaesthesia today. It continues to be referenced nearly 50 years later because of its importance. They introduced the concept of MAC and using it as a standard and comparison of potency of inhalational agents.