CRASH, Bang, Wallop, what a head injury! Now do I need some steroids?

Roberts I, Yates D, Sandercock P et al. Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Lancet 2004; 364: 1321-1328.

RHH Journal Club. February 16th, 2012. Dr Pavan Kumar

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Do patients with acute head injury, treated with methylprednisolone have improvements in mortality or neurological outcome?

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The devil’s in the detail. A cautionary tale of steroids and spinal cord injury

Bracken MB, Shepard MJ, Collins WF et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury: results of the Second National Acute Spinal Cord Injury Study. New England Journal of Medicine 1990; 322: 1405-1411.

RHH Journal Club. February 16th, 2012. Dr Kirsty Parsons

Full-text article (if available) 

Do patients with acute spinal-cord injury, treated with methylprednisolone (in doses higher than in NASCIS I) or naloxone, have improvements in their neurological function?

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