Early-goal directed therapy in sepsis – a flawed concept?

Rivers E, Nguyen B, Havstad S et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. New England Journal of Medicine 2001; 345: 1368-1377.

RHH Journal Club. June 13th, 2013. Dr Wei Yang Low

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Does early goal-directed therapy before admission to the intensive care unit effectively reduce the incidence of multiorgan dysfunction, mortality, and the use of health care resources among patients with severe sepsis or septic shock?

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Salt is better than sugar

Myburgh JA, Finfer S, Bellomo R et al. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. New England Journal of Medicine 2012; 367: 1901-1911.

RHH Journal Club. November 22nd, 2012. Dr Balaji Kasa

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To evaluate the safety and efficacy of 6% HES (130/0.4) in 0.9% saline as compared to 0.9% saline alone for fluid resuscitation in ICU.

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