Rivers E, Nguyen B, Havstad S et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. New England Journal of Medicine 2001; 345: 1368-1377.
RHH Journal Club. June 13th, 2013. Dr Wei Yang Low
Full-text article (if available)
Does early goal-directed therapy before admission to the intensive care unit effectively reduce the incidence of multiorgan dysfunction, mortality, and the use of health care resources among patients with severe sepsis or septic shock?